Leo's channel: www.youtube.com/c/LeoandLongevity/
📩 Automatically receive MPMD articles when they are published: bit.ly/2mtASGW
💊 gorillamind.com/derek (Gorilla Mind - My Fully Loaded Nootropic Formulas) coupon code "DC10" for 10% off your entire order
🦍 gorillamode.com/derek (Gorilla Mode - My Turnkey Pre-Workout Formulas) coupon code "DC10" for 10% off your entire order
⚕️ My TRT Clinic: bit.ly/373k791
🧪 Blood Work: bit.ly/2wI3k9J
⚕️ Pharma Grade Hair Loss Treatments: bit.ly/3fG20t2
🧴 The Best Hair Loss Prevention Shampoo & Fast-Drying/Non-Oily Minoxidil: bit.ly/2GUtgV2 | discount code "MPMD" for 20% off your entire order
🧴 The Skincare Products I Use: bit.ly/3pdS2DO - coupon code "DC10" for 10% off your entire order
🥩 The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): bit.ly/2JmpTGv
🧵 www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) coupon code "MPMD" for 15% off your entire order
Follow Me On
Subscribe To The More Plates More Dates Podcast
Apple Podcasts: podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
#MorePlatesMoreDates #Anadrol #Bodybuilding
So anadra has an immediate impact on your strength.
If you take, if you take anadrol an hour before an event, you immediately get stronger and that's because of adrenergic signaling.
Usually it's anadrol people go into the competitions.
Usually you'll see the especially the super heavyweights.
On the day of the competition, you'll see them blue.
If they're white people they'll they look like blue because of the amount of anadrol they took where they are.
I don't know what it does to blood circulation, but it ends up being where you look a little bit blue and like you've, just died, but but wow that's one of the most confusing compounds when you actually look at the pharmacodynamics of it and how it's working, it's like inherently like prevents estrogen clearance, and then it's also like progestogenic.
Somehow, even though it's chemical structure as a dht derivative, it's like one of the most confusing anabolics I've ever seen to learn and it also its affinity for the androgen receptors undetectable.
It's like what the [ __ ] is going on with that compound.
Why do you say the affinity for the androgen receptors undetectable? I never heard of that before.
Oh you've, never seen like the binding assay studies where they check, you know relative to primo relative to nandrolone and it was like the lowest ones were like d-ball um.
I don't remember what they were, but at the very bottom of the totem pole.
Anadrol was undetectable and it's binding affinity for ar so.
But the thing about binding affinities right is that they say nothing about the efficiency or efficacy of of uh, causing response elements from the binding.
So, for example, you can have something that doesn't have a strong affinity for the androgen receptor, but when it does bind to it causes an immediate response right right or you can have something like.
Are you that thing that stuff you guys use where that just holds on to the receptor, but doesn't activate it? That fully right so, like I would assume.
Anadrol has a lot of like satellite interactions with other receptors that you would not traditionally think of, because everyone just thinks how potent of an agonist of the ar is it.
But I've never seen anyone give like an elaborate good explanation of how it's doing what it's doing.
I don't know that'd be interesting for you to touch on.
My impression I thought personally was that it was affecting the androgen receptor as well as the progesterone receptor.
I thought those two for sure it was affecting and then probably the mineral corticoid and glucocorticoids doing something there as well.
I have some notes on it as well, but I never thought that it wasn't activating the androgen receptor there's no way because that no it definitely does it's just the affinity is so low that it was undetectable based on the binding assay so like.
Presumably it's still doing something, it's just not as potent as the others, but I guess that doesn't even factor in like dissociation rates or any of this kind of stuff that no one else like everyone just looks at how what is the binding affinity and that's it? No one thinks about glucocorticoid interaction.
No one thinks about you know progestogenic any of that skin stuff.
So but it's very potent to what it does.
So it's just kind of interesting to me, yeah that I mean that's what I love about your channels, you're the first person that doesn't just talk about the androgenic signaling.
Nobody else seems to have this idea that there are other signaling there's other kinds of signaling going on, and it doesn't really depend on the nature of the molecule like if it looks like a dht molecule, it doesn't mean like it.
Acts like one small alterations in the molecule structure, cause it to bind to different places and do all kinds of different things, but in terms of anadrol yeah, so anadrol has an immediate impact on your strength.
If you take, if you take anadrol an hour before an event, you immediately get stronger and that's because of adrenergic signaling.
So that's like sympathetic drive enhancement relative to something else.
So it's like more potent at that than a traditional, more tissue, selective anabolic, like I thought I don't know like how.
How does it facilitate that in a way? That's any better than something else if it's not inherently like inherently andral is like somewhat tolerable at like reasonable dosages among women.
So it's not like super androgenic milligram per milligram so like.
How does it facilitate that more than something else, I do think it's more androgenic milligram per milligram, but I know what you're talking about.
There are studies in which you don't have children and women that are well tolerating it at dosages, relate like actually comparable to what men are using for bodybuilding purposes, so you would think at a much lower dosage and I've actually seen women deploy this in their performance, enhancing protocols to avoid masculinization as if they get a low enough dose.
If an underground lab is willing to dose it low enough and they don't have like a 50 milligram a-bomb and you can actually cut it into small enough pieces.
A girl can get away with like five milligrams potentially and get significant performance enhancement with a relative lack of masculinization that you'd get with some other compound.
How would that compare to dianabol for a woman like five milligrams? Would they get more well traditionally, apparently, 10 milligrams is enough to give therapeutic androgen replacements in men like clinically back in the 60s or 70s or whatever it was.
You can replace your entire endogenous androgen production sufficiently with only 10 milligrams of dianabol, so that in women is too much.
So it's just it.
I don't know it's kind of weird, because some of the numbers are uh more favorable for anadrol in a lot of cases, and it just seems like the dosages used might just be too high for what people are using well, I definitely think doses are that are too high, but also isn't it interesting to comment on the fact that both trend balloon and anadrol, which are the two compounds that cause the most acute strength gains, are both appear to be at least progestogenic right yeah.
So they made it definitely and I think, also their effect, which people think has something to do with estrogen and that water retention effect is probably also just the progesterone receptor signaling, which makes the body more sensitive to estrogen, because it up regulates estrogen receptors.
There was uh some some really obscure study.
Somebody sent me recently, apparently uh anadrol inherently, even though it's not a substrate for aromatase.
It has a very high binding affinity for er alpha.
So that's how they think it might be exerting its effects, and then I forget how they said it was, but apparently it inhibits estrogen clearance like its metabolism, so it can cause like not an up regulation, but more so like prevents you from getting rid of it properly.
So you have more of an estrogenic burden, just with your other, whatever agents that you're using.
So I don't know- maybe that's how it works too.
Yeah these things are that's very interesting.
These things are not entirely straightforward.
They they're- I mean I've, noticed this because, like in the last year or so, I've been really interested in learning about neuroscience and what I've? What I've realized is that so many molecules affect so many random receptors in the body that you wouldn't expect the effect like, for example, um melatonin agonizes, the rxr and ror receptors, which are agonized by that acne medication uh.
I forgot what it's called accutane accutane, exactly it's a vitamin e, that's what the the vitamin e receptor, rxr and ror is actually a um, a target of melatonin which we take before bed, so random molecules, agonize, random receptors, and we really like when we see the results of these steroids.
I feel like we really don't realize what is uh.
I mean we blame it on androgen signaling, but it could be all kinds of things going on in the body that is causing these results.
Anadrol-50 is an extremely powerful bodybuilding tool for muscle hypertrophy. There is research and evidence backing its potential for growing muscle mass and adding to workout efficiency. Plus, it is an oral drug, so the chances of liver toxicity are quite low.Is Oxymetholone good for bodybuilding? ›
Oxymetholone is highly effective in promoting extensive gains in body mass, mostly by greatly improving protein synthesis. For this reason, it is often used by bodybuilders and athletes.How long does it take to see results from Anadrol? ›
Anadrol cycle results
In fact, experts regard Anadrol as one of the most potent substances to boost muscle mass growth. The cycle causes the user to feel their strength increase within a few weeks of consumption. To quantify this surge, some have seen an increase of over 25 pounds in lifting weights within ten days.
Testosterone is the hormone responsible for the development of male characteristics, such as increased muscle mass and strength, and Anadrol can help to increase your levels of testosterone.How much Anadrol do bodybuilders take? ›
Male bodybuilders will often take 50-100mg of Anadrol per day for 4-8 weeks. An effective dose for women looking to build muscle is 12.5-25mg per day for 4-6 weeks. Due to Anadrol's short half-life of 5-9 hours (21), doses should be split up and taken regularly throughout the day.
As such, it is important to know how to cycle Anadrol safely before using it. Anadrol should typically be used for 4-6 weeks at a time, followed by a break of at least 2 weeks. This will help to minimize the risk of side effects such as liver damage, high blood pressure, and testosterone suppression.How quickly does oxymetholone work? ›
It may take 3 to 6 months before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. This medicine can cause unusual results with certain medical tests.How do you feel on Anadrol? ›
Serious side effects of Anadrol-50
Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up. Pimples (acne). Shortness of breath, a big weight gain, or swelling in the arms or legs.
Some of the most common Anadrol withdrawal symptoms might include: Feelings intense fatigue. Nausea and vomiting. Muscle aches and joint pain.What time of day should I take Anadrol? ›
The typical daily dose for adults is 1 to 5 mg/kg of body weight. Athletes who compete in powerlifting and bodybuilding may need to take doses up to 10-15 mg/kg daily. To prevent stomach disturbance, Anadrol should be taken with meals. You can take it with milk or food if this doesn't work.
The recommended daily dose in children and adults is 1-5 mg/kg of body weight per day. The usual effective dose is 1-2 mg/kg/day but higher doses may be required, and the dose should be individualized. Response is not often immediate, and a minimum trial of three to six months should be given.Does Anadrol make it hard to sleep? ›
excitation, restlessness, trouble sleeping (insomnia), or. breast swelling in men.Are Anadrol gains permanent? ›
The results of Anadrol can be seen in a matter of weeks, with some people seeing an increase in muscle mass of up to 20%. However, the results of Anadrol are not permanent and will only last as long as the person is taking the steroid. Once they stop taking Anadrol, their muscle mass will slowly decrease over time.What is Anadrol best for? ›
Anadrol (oxymetholone) is a medication used to treat anemia. It stimulates the production of erythropoietin (EPO), a hormone made by your kidneys that's important for producing red blood cells.What is the best steroid for increasing testosterone? ›
- TestoPrime - Top Choice.
- Prime Male - Best Choice for minimizing estrogen conversion.
- Testofuel - Top choice for boosting libido.
- Testo-Max - The natural TRT alternative.
- Testo Lab Pro - Best choice for every day use.
During the steroid cycle, if users lift heavy weights, maintain a healthy diet plan and do whatever the cycle requires, they can easily add up to 20 pounds of lean muscle mass within 60 days.Is oxymetholone strong? ›
Oxymetholone has been said to be one of the most powerful androgenic anabolic steroids available for medical use. It has been proposed that prolonged use of oxymetholone may cause liver-cell damage or hyperplasia, carcinogenicity and reproductive toxicity.What is oxymetholone 50 mg used for? ›
What is this medication? OXYMETHOLONE is a steroid. This medicine is used to treat anemia.Which steroid is best for building muscle? ›
Dianabol is universally considered to be the most effective steroid for muscle gains and strength. If you want to really turbocharge your results a steroid bulking stack is advised. Combining or stacking 4 anabolic steroids can help you gain muscle mass quickly and help you stay swole for longer.What is the safest anabolic steroid? ›
Available in both oral and injectable forms, testosterone is widely prescribed to treat low testosterone levels and is considered the safest oral steroid.
If a person experiences insomnia while taking prednisone, taking the medication in the morning may help minimize the disruption to the sleep-wake cycle. Alternatively, a doctor may suggest splitting the dose between morning and night.Does Anadrol cause anger? ›
From these most frequently used types of AAS, only Anadrol (oxymetholone) is anecdotally associated with increased aggression in humans (70, 71).Is Anadrol better than Dianabol? ›
A typical dosage of Anadrol is 50-100mg/day, whereas Dianabol's is 20-40mg/day. Thus, Dianabol is actually the more potent steroid mg for mg, but because Anadrol is typically taken in higher quantities; side effects can be a little more troublesome in our experience.Can you stay on steroids indefinitely? ›
Steroids should ideally only be used for a short period of time to get over a flare-up or while long term treatments, such as azathioprine, become established. If you are starting a course of steroids, then you should complete the full reducing course, which is generally prescribed for eight weeks.How long should you cycle Anadrol? ›
Cycle Duration: An Anadrol cycle usually lasts between 4 to 6 weeks. Longer cycles are generally not recommended because of the increased risk of side effects and severe liver damage. Dosage: Anadrol dosage can range from 25 mg to 100 mg per day.What is the strongest anabolic steroid in the world? ›
Dimethyltrienolone is an extremely potent agonist of the androgen and progesterone receptors and hence AAS and progestogen. In animal bioassays, it was shown to possess more than 100 times the anabolic and androgenic potency of the reference AAS methyltestosterone.What is the most expensive steroids for bodybuilding? ›
Crazy Bulk Ultimate Stack is one of the most expensive steroid stacks. A high price tag of $274.99 might be intimidating for some consumers. However, the price is worth it since it contains powerful ingredients scientifically proven to increase muscular growth, strength, and stamina.What are the best steroids to build muscle and lose fat? ›
Anavar, Winstrol, Clenbuterol, and Sustanon are all popular and best steroids for cutting cycles that can help burn fat, preserve muscle mass, and improve athletic performance.What is the best cycle for lean mass? ›
Deca Durabolin (Best for Lean Muscle Mass Development) Deca Durabolin is the brand name for the steroid Nandrolone. It's a very popular bulking steroid and one of the best choices for beginners. However, beginners who cycle Deca Durabolin need to be okay with taking the steroid via intramuscular injection.What are the benefits of taking Anadrol? ›
Anadrol (oxymetholone) is a medication used to treat anemia. It stimulates the production of erythropoietin (EPO), a hormone made by your kidneys that's important for producing red blood cells.
Here is an anabolic steroid that helps improve the body's overall functioning and enhances mental health. Anadrol is a new muscle-building product for athletes and bodybuilders. This product consists of natural and healthy ingredients that support better stamina, strength and energy level.How to take Anadrol for best results? ›
The recommended daily dose of Anadrol-50 in children and adults is 1-5 mg/kg body weight per day. The usual effective dose is 1-2 mg/kg/day but higher doses may be required, and the dose is individualized. Response is not often immediate, and three to six months should be given.Will I lose muscle if I stop taking Anadrol? ›
Within just a few weeks of coming off of the drug, abusers may notice a dramatic decrease in their muscle mass and strength. And the fear of that alone can often be enough to keep on using. Withdrawal is the second reason abusers feel a drive to keep on abusing Anadrol. And it can be just as powerful as the first.What steroids are best to keep gains after? ›
- Dianabol - Best choice for muscle building (Most Popular)
- Deca Durabolin - Best choice for stamina.
- Trenbolone - Best choice for muscle mass and recovery.
- Sustanon - Best choice for testosterone levels.
- Dbal Max.
- Brutal Force Dbulk.
- Crazy Bulk Trenorol.
- Primegenix Testodren.