Deciphering Anadrol (Oxymetholone) - The Most Misunderstood Mass Builder? (2023)

Introduction

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Content

So anadra has an immediate impact on your strength.

If you take, if you take anadrol an hour before an event, you immediately get stronger and that's because of adrenergic signaling.

Usually it's anadrol people go into the competitions.

Usually you'll see the especially the super heavyweights.

On the day of the competition, you'll see them blue.

If they're white people they'll they look like blue because of the amount of anadrol they took where they are.

I don't know what it does to blood circulation, but it ends up being where you look a little bit blue and like you've, just died, but but wow that's one of the most confusing compounds when you actually look at the pharmacodynamics of it and how it's working, it's like inherently like prevents estrogen clearance, and then it's also like progestogenic.

Somehow, even though it's chemical structure as a dht derivative, it's like one of the most confusing anabolics I've ever seen to learn and it also its affinity for the androgen receptors undetectable.

It's like what the [ __ ] is going on with that compound.

Why do you say the affinity for the androgen receptors undetectable? I never heard of that before.

Oh you've, never seen like the binding assay studies where they check, you know relative to primo relative to nandrolone and it was like the lowest ones were like d-ball um.

I don't remember what they were, but at the very bottom of the totem pole.

Anadrol was undetectable and it's binding affinity for ar so.

But the thing about binding affinities right is that they say nothing about the efficiency or efficacy of of uh, causing response elements from the binding.

So, for example, you can have something that doesn't have a strong affinity for the androgen receptor, but when it does bind to it causes an immediate response right right or you can have something like.

Are you that thing that stuff you guys use where that just holds on to the receptor, but doesn't activate it? That fully right so, like I would assume.

Anadrol has a lot of like satellite interactions with other receptors that you would not traditionally think of, because everyone just thinks how potent of an agonist of the ar is it.

But I've never seen anyone give like an elaborate good explanation of how it's doing what it's doing.

I don't know that'd be interesting for you to touch on.

My impression I thought personally was that it was affecting the androgen receptor as well as the progesterone receptor.

I thought those two for sure it was affecting and then probably the mineral corticoid and glucocorticoids doing something there as well.

I have some notes on it as well, but I never thought that it wasn't activating the androgen receptor there's no way because that no it definitely does it's just the affinity is so low that it was undetectable based on the binding assay so like.

Presumably it's still doing something, it's just not as potent as the others, but I guess that doesn't even factor in like dissociation rates or any of this kind of stuff that no one else like everyone just looks at how what is the binding affinity and that's it? No one thinks about glucocorticoid interaction.

No one thinks about you know progestogenic any of that skin stuff.

So but it's very potent to what it does.

So it's just kind of interesting to me, yeah that I mean that's what I love about your channels, you're the first person that doesn't just talk about the androgenic signaling.

Nobody else seems to have this idea that there are other signaling there's other kinds of signaling going on, and it doesn't really depend on the nature of the molecule like if it looks like a dht molecule, it doesn't mean like it.

Acts like one small alterations in the molecule structure, cause it to bind to different places and do all kinds of different things, but in terms of anadrol yeah, so anadrol has an immediate impact on your strength.

If you take, if you take anadrol an hour before an event, you immediately get stronger and that's because of adrenergic signaling.

So that's like sympathetic drive enhancement relative to something else.

So it's like more potent at that than a traditional, more tissue, selective anabolic, like I thought I don't know like how.

How does it facilitate that in a way? That's any better than something else if it's not inherently like inherently andral is like somewhat tolerable at like reasonable dosages among women.

So it's not like super androgenic milligram per milligram so like.

How does it facilitate that more than something else, I do think it's more androgenic milligram per milligram, but I know what you're talking about.

There are studies in which you don't have children and women that are well tolerating it at dosages, relate like actually comparable to what men are using for bodybuilding purposes, so you would think at a much lower dosage and I've actually seen women deploy this in their performance, enhancing protocols to avoid masculinization as if they get a low enough dose.

If an underground lab is willing to dose it low enough and they don't have like a 50 milligram a-bomb and you can actually cut it into small enough pieces.

A girl can get away with like five milligrams potentially and get significant performance enhancement with a relative lack of masculinization that you'd get with some other compound.

How would that compare to dianabol for a woman like five milligrams? Would they get more well traditionally, apparently, 10 milligrams is enough to give therapeutic androgen replacements in men like clinically back in the 60s or 70s or whatever it was.

You can replace your entire endogenous androgen production sufficiently with only 10 milligrams of dianabol, so that in women is too much.

So it's just it.

I don't know it's kind of weird, because some of the numbers are uh more favorable for anadrol in a lot of cases, and it just seems like the dosages used might just be too high for what people are using well, I definitely think doses are that are too high, but also isn't it interesting to comment on the fact that both trend balloon and anadrol, which are the two compounds that cause the most acute strength gains, are both appear to be at least progestogenic right yeah.

So they made it definitely and I think, also their effect, which people think has something to do with estrogen and that water retention effect is probably also just the progesterone receptor signaling, which makes the body more sensitive to estrogen, because it up regulates estrogen receptors.

There was uh some some really obscure study.

Somebody sent me recently, apparently uh anadrol inherently, even though it's not a substrate for aromatase.

It has a very high binding affinity for er alpha.

So that's how they think it might be exerting its effects, and then I forget how they said it was, but apparently it inhibits estrogen clearance like its metabolism, so it can cause like not an up regulation, but more so like prevents you from getting rid of it properly.

So you have more of an estrogenic burden, just with your other, whatever agents that you're using.

So I don't know- maybe that's how it works too.

Yeah these things are that's very interesting.

These things are not entirely straightforward.

They they're- I mean I've, noticed this because, like in the last year or so, I've been really interested in learning about neuroscience and what I've? What I've realized is that so many molecules affect so many random receptors in the body that you wouldn't expect the effect like, for example, um melatonin agonizes, the rxr and ror receptors, which are agonized by that acne medication uh.

I forgot what it's called accutane accutane, exactly it's a vitamin e, that's what the the vitamin e receptor, rxr and ror is actually a um, a target of melatonin which we take before bed, so random molecules, agonize, random receptors, and we really like when we see the results of these steroids.

I feel like we really don't realize what is uh.

I mean we blame it on androgen signaling, but it could be all kinds of things going on in the body that is causing these results.